Glycation is the process by which a protein molecule harmfully crosslinks with a sugar molecule. Glycation creates toxic inflammatory pigments known as advanced glycation end products or AGEs. AGEs speed up oxidative damage (especially to connective tissue such as collagen and elastin), and have been linked to the cosmetic signs of aging and the progression of age related disease. Glycation of collagen and elastin in skin causes the accumulation of AGEs, inducing skin damage and a hardening of the collagen network, eventually leading to the death of collagen fibroblasts.
Several in vitro studies have shown Oryza Sakura Extract to possess an anti-glycation affect through an ability to reduce AGE production and the loss of skin fibroblast cells needed for collagen formation. A double-blind placebo controlled human clinical trial has also been undertaken by Oryza to evaluate the effect on skin appearance and beauty. The results of the study found that sakura extract reduced skin AGEs, suppressed loss of elasticity, reduced pigmentation and redness, aided moisture retention and improved smoothness of the skin. Click below for more information and links to clinical studies.